Computational algorithm of high-intensity focused ultrasound beam of cancer tissue model for hyperthermia therapy

Kitsakorn Locharoenrat

Abstract


Ultrasound source mask is applied to generate high intensity focused ultrasound radiation force in 2D model of human breast carcinoma for hyperthermia therapy. Computational operation is based on Pennes bioheat’s concept. This method provides precise heat transfer values relied on thermal conduction in soft tissue and thermal convection in blood vessel domain. Ultrasound beam at 1 MHz is firstly lateral focused in tumor size of 15.0 mm x 28.5 mm at different focal depths without elevational focalization. Length of each focusing point of ultrasound beam is 6.8 – 45.4 mm in vertical axis, whereas full width at half maximum is 1.1 – 2.5 mm in horizontal axis. Simulated results have been shown that a discrepancy of ultrasound pressure around focus area rises with focal depth. Like pressure profile, when focal depth closes to ultrasound source, thermal homogeneity around focus area is attained, whereas thermal uniformity around focus area becomes worse with increasing focal depth. Using data visualization arrangement, acquired temperature profile corresponding to obtained pressure profile is converted to attain image of 2D model of human breast carcinoma. It is seen that ablated tumors are achieved, whilst normal tissues surrounding them are safe.


Keywords


Pennes bioheat; heat transfer; hyperthermia; tumor; ultrasound

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References


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