Hepatotoxicity of Cassia fistula extracts in experimental chicks and assessment of clinical parameters

Irfana Iqbal, Mohammad Afzal, Muhammad N. Aftab, Farkhanda Manzoor, Afshan Kaleem, Ahmad Kaleem

Abstract


Cassia fistula (Fabaceae) is one of the most commonly used medicinal plants for its antimalarial and antimicrobialactivities. So far, safety of the plant fruit seed as a traditional medicine has not been well investigated. Therefore, theeffect of C. fistula seeds on sub-chronic hepatic toxicity in chicks fed with 30-50 mg/kg methanolic extract of thefruit seeds, for 7-21 days, was investigated. The protective effect of C. fistula on organs and the hematological andbiochemical parameters were examined. At 40 mg/kg dose of C. fistula to chicks showed a non-significant decrease incount of RBCs and other serological values, presumably through a provoked hemolysis of RBCs and/or toxicity of theplant. However, a significant reduction in liver function enzymes (ALP, ALT and AST) urea, and creatinine levels withan increase in plasma protein reflected on its hepato-renal protection. Only nominal pathological lesions were observedin microscopic examination of the chick’s hepatic tissues. We propose that C. fistula fruit seeds are hepatoprotective andrenoprotective.


Keywords


Cassia fistula; hepatoprotective; medicinal plant; renoprotective; serological.

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