Investigation of Terminalia arjuna as potential IL-4 and IL-13 modulator for the prevention of autoimmune diabetes: A Pharmacoinformatics-based study

DOI: 10.48129/kjs.17337

Authors

  • Aziz Unnisa Dept. of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, KSA. https://orcid.org/0000-0002-1080-4542
  • Saheem Ahmad Dept. of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, KSA.
  • Suresh Babu Jandrajupalli Dept. of Preventive Dental Sciences, College of Dentistry, University of Hail, KSA.
  • Kareem M. Younes Dept. of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, KSA.
  • Sally Hassan Abobaker Dept. of Basic Dental and Medical Sciences, College of Dentistry, University of Hail, KSA.
  • Swarnalatha Chandolu Dept. of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, KSA.
  • Mohammad Khalid Dept. of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA
  • Lakshmi Sudeepthi N Dept. of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, A.P, India.

DOI:

https://doi.org/10.48129/kjs.17337

Abstract

Cytokines are proteins that play a critical role in the development, maturation, and functional activities of immune cells. For the first time, we have investigated the potential role of Terminalia arjuna as IL-4 and IL-13 modulators for preventing T1DM, i.e., autoimmune diabetes. It has been well documented that the stimulation of IL-4 and IL-13 can regulate the level of type 2 cytokines which can be maintained with the level of type 1 cytokines. In the present study, gallic acid, arjunolic acid, luteolin, ellagic acid, and arjunone were investigated for their potential modulating activity of IL-4 and IL-13. The active amino acid residues identified for IL-4 are VAL51, HIS58, ASP87, THR30, GLN54, THR63, ARG64, LYS84, and GLU60. The active amino acid residues identified for IL-13 are H: GLU46, H: TRP47, H: GLN61, L: PHE98, L: VAL97, L: GLU162, L: THR163, H: ARG105, L: GLN38, L: ASP85, H: GLY42, L: GLY41, H: PRO41, H: TRP47, and L: PHE98. The phytoconstituents demonstrated better modulating activity towards IL-13 than IL-4. Luteolin displayed better potential for both IL-4 and IL-13, and therefore we concluded that it could be used to modulate the activity of IL-4 and IL-13 for the prevention of autoimmune diabetes.

Author Biographies

Aziz Unnisa, Dept. of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, KSA.

 

 

Saheem Ahmad, Dept. of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, KSA.

Associate Professor, 

Department of Medical Laboratory Sciences,

College of Applied Medical Sciences,

University of Hail, KSA.

 

Suresh Babu Jandrajupalli, Dept. of Preventive Dental Sciences, College of Dentistry, University of Hail, KSA.

 

 

Kareem M. Younes, Dept. of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, KSA.

Department of Pharmaceutical Chemistry, College of Pharmacy, University of
Hail, Hail, KSA.

 

Sally Hassan Abobaker, Dept. of Basic Dental and Medical Sciences, College of Dentistry, University of Hail, KSA.

 

 

Swarnalatha Chandolu, Dept. of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, KSA.

 

 

Mohammad Khalid, Dept. of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA

Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin
Abdulaziz University, Al-Kharj, KSA

 

Lakshmi Sudeepthi N, Dept. of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, A.P, India.

 

 

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Published

08-01-2023

Issue

Vol. 50 No. 1A (2023): Kuwait Journal of Science

Section

Biology