Effect of Trianthema triquetra Rottl. ex Willed (Aizoaceae) on ethanol induced gastric ulcers in experimental rats and assessment of various ulcer parameters
Keywords:Ethanol, Gastric-ulcer, NSAID's, Omeprazole, Trianthema triquetra
Trianthema triquetra Rottl. Ex.Willed is a medicinal plant that belongs to the family Aizoaceae. The plant has been used traditionally as fodder , as remedy for chronic ulcer, chronic fever and also for the healing of wounds. Therefore the present study was intended to investigate the anti-ulcer ability of different fractions of Trianthema triquetra to verify its folklore use in ulcer cure. Anti-ulcer potential of butanol, chloroform, ethyl acetate and an aqueous fraction of crude methanolic extract of Trianthema triquetra were assessed by using ethanol- induced gastric ulcer model in rats. Omeprazole at a dose of 20 mg/kg was used as standard drug .After 30 minutes of administration of test dose, the gastric ulcer was induced in all animals by the administration of absolute ethanol (1ml/animal) orally except normal control animal group. After an hour, all the rats were sacrificed. Ulcer index, %age of ulcer inhibition, gastric pH, gastric volume, total acidity, gastric wall protein, gastric wall mucus and histopathology of stomach wall of rats were assessed. All the fractions of T. triquetra at a dose of 300mg/kg body weight showed a substantial decrease in ulcer index and an improvement in percentage inhibition in comparison to the ulcer control group. There was a rise in the amount of gastric wall mucus content, total protein content, gastric pH and a decrease in gastric volume and total acidity. The present work encourages the conventional use of T. triquetra in the cure of ulcer. Moreover, Hispathological studies showed severe mucosal injury, leucocyte infiltration and edema in disease control animal group as compared to omeprazole treated and plant fractions treated animal groups.
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